Mammalian Cell Line Development
A Successful Process Starts with Great Producer Cell Lines
One of Cytovance’s core services is recombinant protein drug substance production derived from mammalian cell culture. The key to our expression success is our talented team’s world-class cell line development services that help select the perfect clone for each product.
Leverage Our Experience to Develop Your Ideal Clone
With over 20 years in mammalian-based protein production, our experience and culture of ingenuity offer significant benefits to therapeutic developers. Using the trusted ThermoFisher Scientific FreedomTM CHO S system, we have developed an iterative development process that starts with a pool of thousands of transfected clones that are subsequently narrowed down to identify your product’s ideal candidates. We find the right clone through single-cell cloning via the Namocell and productivity and clonal stability studies using shake flasks or Ambr® 15 mini bioreactors. With the seamless integration of analytics during this process, our approach can enhance the transferability from R&D to Manufacturing and result in multiple benefits for our clients.
Facilitated Development Timelines
Utilizing our custom and platform-based cell line development services, you can expect significant reductions in development time to manufacturing, which can lead to substantial savings in resources and your timeframe to file with the FDA.
Predictable Performance
Deep experience in mammalian cell line development has given our team a thorough understanding of critical parameters through the development process that can affect productivity at a large scale. The result is a highly predictable process, supported by strong data and critical insights.
Lower Cost of Goods
Our iterative cell line development services ensure we can find the highest-producing stable clone that will exhibit the most desirable characteristics in large-scale manufacturing. These favorable expression characteristics will translate to the ideal cost of goods and make the most of your investment.
Related Areas of Expertise
Mammalian Process Development
Take your productivity to the next level with our process development experts.
Mammalian Analytical Development
Robust analytical method development or transfer personalized for your mammalian-derived biologics.
Mammalian Manufacturing
Benefit from our full-service cGMP facility from cell banks to production with up to 2,000L capacity.
Contact Us
Meet Team Cytovance in 2026!
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– BIO Investment and Growth Summit: March 2-3, Miami Beach, FL
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– OPCU Large Molecule: March 24, Virtual
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– World Vaccine Congress: March 30-April 2, Washington D.C. | Booth 536
– PEGS: May 11-15, Boston, MA -
– TIDES USA Oligonucleotide & Peptide Therapeutics: May 11-14, Boston, MA
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– BIO International Convention: June 22-25, San Diego, CA | Booth 4445
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– BioProcess International East: September 22-25, Boston, MA
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– CPHI Europe: October 6-8, Milan, Italy
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– CDMO Live Americas: October 19-21, Boston, MA
- – OPCU Large Molecule: October 27, Virtual