Strain Development

Development of E.coli and Saccharomyces cerevisiae Strains for Robust Manufacturing

As your reliable CDMO partner, we pride ourselves on our track record of over 84 proteins successfully expressed and manufactured in a microbial environment since 2011. Leverage our expertise in strain development to identify and further develop high-quality E.coli  and  Saccharomyces cerevisiae strains that provide excellent expression at manufacturing scales.

What Strain Is Right For Your Project?
Cytovance offers strain development including e. Coli, Pichia, Saccharomyces cerevisiae.

Setting a Strong Foundation for Microbial Manufacturing

A robust manufacturing process begins with the thoughtful development of the ideal strain. Strain development is an extremely important aspect of successful cGMP manufacturing as it will provide critical information regarding scale-up activities, expected yields, product characteristics, and subsequent process unit operations.

When you partner with Cytovance, you gain access to our deep experience in strain development and our innovative KeystoneTM Expression System for jumpstarting any E.coli-based programs. The KeystoneTM Expression System enables unrivaled control over the manufacturing process from the start and the freedom to operate without royalties.

Green Icon of Pichia for microbial CDMO services from Cytovance Biologics.

Strain Development Done Right

For E.coli-based production, our clients will have access to the KeystoneTM Expression System, which offers unrivaled solutions to create productive and robust manufacturing strains. This novel approach developed by Cytovance gives our clients the highest chance of success in manufacturing by creating and subsequently evaluating the performance of multiple strains simultaneously in scaled-down batch and fed-batch formats. To complement this system, our experienced analytical teams leverage the Sartorius Ambr® 250 fully automated, high-throughput bioreactor system to manage multiple experiments while reducing the final cost per experiment.

The Power of Partnerships

Vectron BioSolutions - One-of-a-Kind Strains

Leverage E.coli strains specifically designed to address the complexities of your large molecule thanks to our strategic partnership with Vectron BioSolutions. With access to their sophisticated expression technology platform, your microbial fermentation project can benefit from higher titers and reduced downstream costs and processing time.  

Learn About Custom Strains
Phenotypeca - A Biofoundry of Possibilities

Benefit from our strategic collaboration with Phenotypeca, a producer of high-quality, next-generation baker’s yeast for recombinant protein production. With access to their impressive biofoundry, we can optimize the right, high-quality Saccharomyces cerevisiae-based cell lines for use in your microbial-derived active pharmaceutical ingredients.

Explore Our Collaboration

Streamline Development Costs

Cytovance’s expertly executed strain development services represent an attractive strategy for early risk mitigation in microbial programs. The identification of robust manufacturing strains can significantly reduce project costs and timelines associated with subsequent and potentially drawn-out process development activities.

Related Areas of Expertise

Microbial Process Development

Leverage our experience to get the most from your process.

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Microbial Analytical Development

Robust analytical development personalized for your drug substance or biologic.

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Microbial Manufacturing

Benefit from our full-service cGMP facility with up to 1,000L microbial capacity.

Learn More

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We’re Ready to Learn About Your Project

Meet Team Cytovance in 2026!